Blar i forfatter "Sjaastad, Ivar"

Viser treff 1-2 av 2

    • Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2 

      Boardman, Neoma Tove; Aronsen, J. M.; Louch, William Edward; Sjaastad, Ivar; Willoch, Frode; Christensen, Geir Arve; Sejersted, Ole M; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-01-31)
      Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)2 transports Ca2+ from the cytosol into the sarcoplasmic reticulum of cardiomyocytes and is essential for maintaining myocardial Ca2+ handling and thus the mechanical function of the heart. SERCA2 is a major ATP consumer in excitation-contraction coupling but is regarded to contribute to energetically efficient Ca2+ handling in the cardiomyocyte. ...

    • Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy 

      Rixon, Chloe Louise; Andreassen, Kristine; Shen, Xin; Murugan Erusappan, Pugazendhi; Almaas, Vibeke Marie; Palmero, Sheryl; Dahl, Christen Peder; Ueland, Thor; Sjaastad, Ivar; Louch, William Edward; Stokke, Mathis Korseberg; Tønnessen, Theis; Christensen, Geir; Lunde, Ida Gjervold (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-29)
      Aims Familial hypertrophic cardiomyopathy (HCM) is the most common form of inherited cardiac disease. It is characterized by myocardial hypertrophy and diastolic dysfunction, and can lead to severe heart failure, arrhythmias, and sudden cardiac death. Cardiac fibrosis, defined by excessive accumulation of extracellular matrix (ECM) components, is central to the pathophysiology of HCM. The ECM ...